The twenty-second season will focus on intense, large-scale disasters, including a major bridge collapse bringing in dozens of critically injured patients at Grey Sloan Memorial, alongside high-stakes personnel changes. Dr. Meredith Grey and Dr. Nick Marsh decide to marry after Nick is severely injured in the bridge collapse, with Meredith realizing she doesn't want to let fear dictate her life. The season features the departure of long-time series regulars Dr. Owen Hunt and Dr. Teddy Altman, who leave for a new life in France after surviving a near-fatal plunge in his car during the bridge collapse, marking an end to their long-running storyline.
Episodes
1. Only the Strong Survive
Oct 9, 2025 43m 8.4After the catastrophic hospital explosion, Grey Sloan's staff scrambles to save not only their patients' lives but also their own. Confronted with impossible surgical decisions and emotional turmoil, they fight to preserve life amid devastation.
2. We Built This City
Oct 16, 2025 43m 8.6The team at Grey Sloan navigates a chaotic first day of surgical rotations amid hospital renovations. Meanwhile, Meredith spends time with Amelia.
3. Between Two Lungs
Oct 23, 2025 43m 7.8A high-risk lung transplant pushes the surgical team to their limits. Meanwhile, Bailey juggles a trauma patient whose treatment hangs in the balance.
4. Goodbye Horses
Oct 30, 2025 42m 7.7The interns juggle a bizarre trauma, while a complex breast reconstruction forces Meredith into a tense partnership.
5. Sometimes I Feel Like a Motherless Child
Nov 6, 2025 43m 8.4Jo navigates a challenging case with a pregnant mother, while Blue and Jules care for a diabetic patient. Meanwhile, Simone treats a patient with a surprising revelation.
6. When I Crash
Nov 13, 2025 43m 8.4Grey Sloan takes in patients following a catastrophic bus accident. Teddy and Owen have an awkward encounter, and Richard tests Bailey's patience.
7. Skyfall
Jan 8, 2026 43m 8.0Winston and Ben fight to save Jo's life, while Teddy supports Link. Owen and Jules battle to save a young man, and Lucas forms an unexpected bond with a patient.
8. Heavy on Me
Jan 15, 2026 43m 8.2Bailey and Owen join forces to save a tumor patient, while Richard faces an internal battle. Meanwhile, Jules struggles with her feelings for Winston.
9. Fortunate Son
Jan 22, 2026 42m 8.7Richard continues to navigate his health. Meanwhile, Meredith and Nick are visited by Nick's estranged sister from Boston.
10. Strip That Down
Jan 29, 2026 43m 7.8Addison Montgomery returns to Grey Sloan, seeking assistance with a patient with a neurological condition. Bailey joins Owen and Blue on a paramedic ride-along.
11. (If You Want It) Do It Yourself
Feb 26, 2026 43m 8.0Teddy and Winston clash over a case, while Owen and Jules treat a urologist. Lucas struggles with prioritizing patients.
12. Get Lucky
Mar 5, 2026 43m 8.0Tensions rise as Teddy and Winston take on a complex procedure, while Kavita and Ben try and impress the new plastics attending. Jo and Link leave the babies with a nanny for the first time.
13. Love the Way You Lie
Mar 12, 2026 43m 8.0Richard tackles a shocking case on his first day back, while Kavita and Jules prepare for a high-stakes presentation. Bailey must have a difficult conversation with a beloved patient, and Jo works to baby-proof the loft.
14. Wrecking Ball
Mar 19, 2026 42m 8.0A couple lands in the hospital with life-altering injuries after a wrecking ball destroys their home. Lucas and Simone struggle to support a young, terminally ill patient, and Richard hosts a prostate screening event.
15. Take Me to the River
Mar 26, 2026 42m 8.0Bailey and Blue are forced to confront the emotional costs of experimental care. Meanwhile, Owen, Teddy, Simone and Dani help out at a busy rural hospital, and Richard attempts to spread information about early prostate screenings to the community.
16. Feel It Still
Apr 2, 2026 43m 8.0Jo returns for her first full day back from leave, and Owen struggles to keep it together when someone close to him is admitted to Grey Sloan. Meanwhile, Bailey navigates hospital leadership.
17. Through the Fire
Apr 30, 2026 43m 7.9A Station 19 firefighter lands in the ER for severe burn treatment, and the team treats an elderly patient impaled by an art structure. A Fox Foundation innovation competition reunites Meredith and Bailey.
18. Bridge over Troubled Water
May 7, 2026 43m 7.5After a catastrophic bridge collapse sends dozens of victims to Grey Sloan, the hospital activates its full disaster response as they race to treat a surge of critically injured patients, including one of their own.